小孩得白癜风好治吗 http://pf.39.net/bdfyy/PaperReading
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CirculatingexosomessuppresstheinductionofregulatoryTcellsvialet-7iinmultiplesclerosis
Kimitoshikimura,et.al
NatureCommunications,
ThefrequencyofdysregulatedFoxp3+regulatoryTcellsisreducedinpatientswithmultiplesclerosis(MS),however,thedetailedmechanismsarenotveryclear.ApproximatelymiRNAshavebeenshowntobedysregulatedacrossvarioustissues,includingbrain,bloodandcerebrospinalfluidfrompatientswithMS.MiRNAcanbestoredinexosomes,whicharesecretedbyvariouscelltypesandcirculatedthroughoutthebody.Inthispaper,theauthorsfoundthatTregcellsfrequencycanbereducedbyexosomesfromMSpatients.MicroarrayanalysisgavetheexplanationthatfourmiRNAs,let-7i,miR-19b,miR-25andmiR-92awereupregulatedinMS
